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Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease
BACKGROUND: Huntington disease (HD) is caused by a polyglutamine expansion of more than 35 units in the huntingtin protein. This expanded repeat length inversely correlates with the age-at-onset (AAO), however, additional genetic factors apart from the expanded CAG repeat size are thought to influen...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3022537/ https://ncbi.nlm.nih.gov/pubmed/21211002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-1 |
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