Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease

BACKGROUND: Huntington disease (HD) is caused by a polyglutamine expansion of more than 35 units in the huntingtin protein. This expanded repeat length inversely correlates with the age-at-onset (AAO), however, additional genetic factors apart from the expanded CAG repeat size are thought to influen...

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Détails bibliographiques
Auteurs principaux: Che, Hong Van B, Metzger, Silke, Portal, Esteban, Deyle, Carolin, Riess, Olaf, Nguyen, Huu Phuc
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022537/
https://ncbi.nlm.nih.gov/pubmed/21211002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-1
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