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Interactions of Actinomycin D with Human Telomeric G-Quadruplex DNA

The G-quadruplex structural motif of DNA has emerged as a novel and exciting target for anticancer drug discovery. The human telomeric G-quadruplex consists of a single strand repeat of d[AGGG(TTAGGG)(3)] that can fold into higher-order DNA structures. Small molecules that selectively target and sta...

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Detalhes bibliográficos
Main Authors: Hudson, Jason S., Brooks, Sonja C., Graves, David E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021945/
https://ncbi.nlm.nih.gov/pubmed/19348506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900203z
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