A functional alternative splicing mutation in human tryptophan hydroxylase-2

The brain serotonergic system has an essential role in the physiological functions of the central nervous system and dysregulation of serotonin (5-HT) homeostasis has been implicated in many neuropsychiatric disorders. The tryptophan hydroxylase-2 (TPH2) gene is the rate-limiting enzyme in brain 5-H...

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Autors principals: Zhang, X, Nicholls, P J, Laje, G, Sotnikova, T D, Gainetdinov, R R, Albert, P R, Rajkowska, G, Stockmeier, C A, Speer, M C, Steffens, D C, Austin, M C, McMahon, F J, Krishnan, K R R, Garcia-Blanco, M A, Caron, M G
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021090/
https://ncbi.nlm.nih.gov/pubmed/20856248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2010.99
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