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Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles

It has long been hypothesized that elastic modulus governs the biodistribution and circulation times of particles and cells in blood; however, this notion has never been rigorously tested. We synthesized hydrogel microparticles with tunable elasticity in the physiological range, which resemble red b...

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Detalhes bibliográficos
Main Authors: Merkel, Timothy J., Jones, Stephen W., Herlihy, Kevin P., Kersey, Farrell R., Shields, Adam R., Napier, Mary, Luft, J. Christopher, Wu, Huali, Zamboni, William C., Wang, Andrew Z., Bear, James E., DeSimone, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021010/
https://ncbi.nlm.nih.gov/pubmed/21220299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010013108
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