MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis
The MDM2 oncogene is overexpressed in 5–10% of human tumours. Its major physiological role is to inhibit the tumour suppressor p53. However, MDM2 has p53-independent effects on differentiation and does not predispose to tumorigenesis when it is expressed in the granular layer of the epidermis. These...
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| Vydáno v: | EMBO J |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2000
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC302089/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11013216/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.19.5135 |
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