Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme

Macrophage inflammatory protein-1 (MIP-1), MIP-1α (CCL3) and MIP-1β (CCL4) are chemokines crucial for immune responses towards infection and inflammation. Both MIP-1α and MIP-1β form high-molecular-weight aggregates. Our crystal structures reveal that MIP-1 aggregation is a polymerization process an...

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Main Authors: Ren, Min, Guo, Qing, Guo, Liang, Lenz, Martin, Qian, Feng, Koenen, Rory R, Xu, Hua, Schilling, Alexander B, Weber, Christian, Ye, Richard D, Dinner, Aaron R, Tang, Wei-Jen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020635/
https://ncbi.nlm.nih.gov/pubmed/20959807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.256
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