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Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes
The small G protein RhoA and its GDP/GTP exchange factors (GEFs) Net and Dbl can transform NIH 3T3 fibroblasts, dependent on the activity of the RhoA effector kinase ROCK. We investigated the role of the cytoskeletal linker protein ezrin in this process. RhoA effector loop mutants which can bind ROC...
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| Publicado en: | EMBO J |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2000
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC302055/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10970850/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.17.4565 |
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