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Region of Difference 2 Contributes to Virulence of Mycobacterium tuberculosis

Mycobacterium bovis BCG strains are live, attenuated vaccines generated through decades of in vitro passage. Because in vitro growth does not select for interaction with the host, it has been hypothesized that genetic loci lost from BCG code for virulence determinants that are dispensable for growth...

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Détails bibliographiques
Auteurs principaux: Kozak, Robert A., Alexander, David C., Liao, Reiling, Sherman, David R., Behr, Marcel A.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019914/
https://ncbi.nlm.nih.gov/pubmed/20974821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00824-10
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