Increased Pulmonary Tumor Necrosis Factor Alpha, Interleukin-6 (IL-6), and IL-17A Responses Compensate for Decreased Gamma Interferon Production in Anti-IL-12 Autovaccine-Treated, Mycobacterium bovis BCG-Vaccinated Mice

Interleukin-12 (IL-12) and IL-23 (which share a p40 subunit) are pivotal cytokines in the generation of protective Th1/Th17-type immune responses upon infection with the intracellular pathogen Mycobacterium tuberculosis. The role of IL-12 and IL-23 in protection conferred by the tuberculosis vaccine...

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Detalhes bibliográficos
Main Authors: Freches, Danielle, Romano, Marta, Korf, Hannelie, Renauld, Jean-Christophe, Van Snick, Jacques, Uyttenhove, Catherine, Huygen, Kris
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Vaccine Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019790/
https://ncbi.nlm.nih.gov/pubmed/21084465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00352-10
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