Spontaneous Mutations in the Plasmodium falciparum Sarcoplasmic/ Endoplasmic Reticulum Ca(2+)-ATPase (PfATP6) Gene among Geographically Widespread Parasite Populations Unexposed to Artemisinin-Based Combination Therapies

Recent reports on the decline of the efficacy of artemisinin-based combination therapies (ACTs) indicate a serious threat to malaria control. The endoplasmic/sarcoplasmic reticulum Ca(2+)-ATPase ortholog of Plasmodium falciparum (PfSERCA) has been suggested to be the target of artemisinin and its de...

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Main Authors: Tanabe, Kazuyuki, Zakeri, Sedigheh, Palacpac, Nirianne Marie Q., Afsharpad, Manada, Randrianarivelojosia, Milijaona, Kaneko, Akira, Marma, Aung Swi Prue, Horii, Toshihiro, Mita, Toshihiro
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology (ASM) 2011
Ábhair:
Mechanisms of Resistance
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019649/
https://ncbi.nlm.nih.gov/pubmed/20956593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01156-10
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