Short Alkylated Peptoid Mimics of Antimicrobial Lipopeptides

We report the creation of alkylated poly-N-substituted glycine (peptoid) mimics of antimicrobial lipopeptides with alkyl tails ranging from 5 to 13 carbons. In several cases, alkylation significantly improved the selectivity of the peptoids with no loss in antimicrobial potency. Using this technique...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Chongsiriwatana, Nathaniel P., Miller, Tyler M., Wetzler, Modi, Vakulenko, Sergei, Karlsson, Amy J., Palecek, Sean P., Mobashery, Shahriar, Barron, Annelise E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2011
Assuntos:
Mechanisms of Action: Physiological Effects
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019626/
https://ncbi.nlm.nih.gov/pubmed/20956607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01080-10
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares