Short Alkylated Peptoid Mimics of Antimicrobial Lipopeptides

We report the creation of alkylated poly-N-substituted glycine (peptoid) mimics of antimicrobial lipopeptides with alkyl tails ranging from 5 to 13 carbons. In several cases, alkylation significantly improved the selectivity of the peptoids with no loss in antimicrobial potency. Using this technique...

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Autors principals: Chongsiriwatana, Nathaniel P., Miller, Tyler M., Wetzler, Modi, Vakulenko, Sergei, Karlsson, Amy J., Palecek, Sean P., Mobashery, Shahriar, Barron, Annelise E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2011
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019626/
https://ncbi.nlm.nih.gov/pubmed/20956607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01080-10
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