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Effects of intrastriatal GDNF on the response of dopamine neurons to 6-hydroxydopamine: Time course of protection and neurorestoration

Glial cell line-derived neurotrophic factor (GDNF) protects dopamine (DA) neurons from 6-hydroxydopamine (6-OHDA) toxicity. We have now explored this protection over 8 weeks following toxin administration. Infusion of Fluoro-Gold (FG) into striatum was followed 1 week later by GDNF (9 μg) or its veh...

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Autori principali: Cohen, Ann D., Zigmond, Michael J., Smith, Amanda D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019295/
https://ncbi.nlm.nih.gov/pubmed/21062624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2010.11.006
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