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Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA non-homologous end-joining
DNA double-strand break (DSB) repair occurs within chromatin and can be modulated by chromatin modifying enzymes. Here we identify the related human histone deacetylases HDAC1 and HDAC2 as two participants in the DNA-damage response (DDR). We show that acetylation of histone H3 lysine 56 (H3K56) is...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3018776/ https://ncbi.nlm.nih.gov/pubmed/20802485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1899 |
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