Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model

Interferons (IFNs) are a first line of defense against viral infection. Herein we describe the use of an adenovirus vectored mouse IFN alpha gene (mDEF201) as a prophylactic and treatment countermeasure in a SARS-CoV-infected BALB/c mouse model. Complete survival protection was observed in mice give...

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Autori principali: Kumaki, Yohichi, Ennis, Jane, Rahbar, Ramtin, Turner, Jeffrey D., Wandersee, Miles K., Smith, Aaron J., Bailey, Kevin W., Vest, Zachary G., Madsen, Jason R., Li, Joseph K.-K., Barnard, Dale L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier B.V. Published by Elsevier B.V. 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018546/
https://ncbi.nlm.nih.gov/pubmed/21093489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2010.11.007
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