Design principles of nuclear receptor signaling: how complex networking improves signal transduction

The topology of nuclear receptor (NR) signaling is captured in a systems biological graphical notation. This enables us to identify a number of ‘design' aspects of the topology of these networks that might appear unnecessarily complex or even functionally paradoxical. In realistic kinetic model...

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Autores principales: Kolodkin, Alexey N, Bruggeman, Frank J, Plant, Nick, Moné, Martijn J, Bakker, Barbara M, Campbell, Moray J, van Leeuwen, Johannes P T M, Carlberg, Carsten, Snoep, Jacky L, Westerhoff, Hans V
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018161/
https://ncbi.nlm.nih.gov/pubmed/21179018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2010.102
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