Tobramycin disposition in ICU patients receiving a once daily regimen: population approach and dosage simulations

AIM: The aim of this study was to evaluate the disposition of tobramycin (TOB) in critically ill patients (ICU) by a population pharmacokinetic approach, to determine the covariates involved, and to simulate tobramycin dosage regimens. METHODS: Forty-nine adult ICU patients received TOB (5 mg kg(−1)...

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Autores principales: Conil, Jean-Marie, Georges, Bernard, Ruiz, Stéphanie, Rival, Thomas, Seguin, Thierry, Cougot, Pierre, Fourcade, Olivier, Pharmd, Georges Houin, Saivin, Sylvie
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2011
Materias:
Pharmacokinetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018027/
https://ncbi.nlm.nih.gov/pubmed/21143502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03793.x
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