Biochemical Correction of X-CGD by a Novel Chimeric Promoter Regulating High Levels of Transgene Expression in Myeloid Cells

X-linked chronic granulomatous disease (X-CGD) is a primary immunodeficiency caused by mutations in the CYBB gene encoding the phagocyte nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase catalytic subunit gp91(phox). A recent clinical trial for X-CGD using a spleen focus-forming virus (SFF...

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Detalhes bibliográficos
Main Authors: Santilli, Giorgia, Almarza, Elena, Brendel, Christian, Choi, Uimook, Beilin, Chiara, Blundell, Michael P, Haria, Sneha, Parsley, Kathryn L, Kinnon, Christine, Malech, Harry L, Bueren, Juan A, Grez, Manuel, Thrasher, Adrian J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017453/
https://ncbi.nlm.nih.gov/pubmed/20978475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.226
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