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Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectations
BACKGROUND: Genome-wide association studies give insight into the genetic basis of common diseases. An open question is whether the allele frequency distributions and ancestral vs. derived states of disease-associated alleles differ from the rest of the genome. Characteristics of disease-associated...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3017004/ https://ncbi.nlm.nih.gov/pubmed/21143973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-3-57 |
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