Selection of bead-displayed, PNA-encoded chemicals

The lack of efficient identification and isolation methods for specific molecular binders has fundamentally limited drug discovery. Here, we have developed a method to select peptide nucleic acid (PNA) encoded molecules with specific functional properties from combinatorially generated libraries. Th...

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Autori principali: Gassman, Natalie R., Nelli, J. Patrick, Dutta, Samrat, Kuhn, Adam, Bonin, Keith, Pianowski, Zbigniew, Winssinger, Nicolas, Guthold, Martin, Macosko, Jed C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016959/
https://ncbi.nlm.nih.gov/pubmed/19957300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmr.1007
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