Oxidative Stress Impairs Vasorelaxation Induced by the Soluble Guanylyl Cyclase Activator BAY 41-2272 in Spontaneously Hypertensive Rats

BACKGROUND: BAY 41-2272 (5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidin-4-ylamine) relaxes mesenteric arteries (MA) in a synergistic fashion with nitric oxide (NO). We hypothesized that the relaxation to BAY 41-2272 is decreased in spontaneously hypertensive rats (SHR...

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Autori principali: Priviero, Fernanda B.M., Zemse, Saiprasad M., Teixeira, Cleber E., Webb, R. Clinton
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016715/
https://ncbi.nlm.nih.gov/pubmed/19247264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ajh.2009.18
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