Tonic Premarin dose-dependently enhances memory, affects neurotrophin protein levels and alters gene expression in middle-aged rats

Premarin™ is the most commonly prescribed estrogenic component of hormone therapy, given since 1942. The current study is the first examining cognitive effects of tonic Premarin treatment in an animal model. Middle-aged ovariectomized (Ovx) rats received vehicle or one of three doses of Premarin (12...

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Main Authors: Engler-Chiurazzi, Elizabeth, Tsang, Candy, Nonnenmacher, Sean, Liang, Winnie S., Corneveaux, Jason J., Prokai, Laszlo, Huentelman, Matthew J., Bimonte-Nelson, Heather A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016463/
https://ncbi.nlm.nih.gov/pubmed/19883953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2009.09.005
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