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Cloud computing and validation of expandable in silico livers

BACKGROUND: In Silico Livers (ISLs) are works in progress. They are used to challenge multilevel, multi-attribute, mechanistic hypotheses about the hepatic disposition of xenobiotics coupled with hepatic responses. To enhance ISL-to-liver mappings, we added discrete time metabolism, biliary eliminat...

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Hlavní autoři: Ropella, Glen EP, Hunt, C Anthony
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016276/
https://ncbi.nlm.nih.gov/pubmed/21129207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-4-168
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