Differential effects of the phosphatidylinositol 4-kinases, PI4KIIα and PI4KIIIβ, on Akt activation and apoptosis

In this study, we investigated the role of PI4P synthesis by the phosphatidylinositol 4-kinases, PI4KIIα and PI4KIIIβ, in epidermal growth factor (EGF)-stimulated phosphoinositide signaling and cell survival. In COS-7 cells, knockdown of either isozyme by RNA interference reduced basal levels of PI4...

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Main Authors: Chu, K M E, Minogue, S, Hsuan, J J, Waugh, M G
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2010
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3015391/
https://ncbi.nlm.nih.gov/pubmed/21218173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2010.84
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