Reduced Expression of the ROCK Inhibitor Rnd3 Is Associated with Increased Invasiveness and Metastatic Potential in Mesenchymal Tumor Cells

BACKGROUND: Mesenchymal and amoeboid movements are two important mechanisms adopted by cancer cells to invade the surrounding environment. Mesenchymal movement depends on extracellular matrix protease activity, amoeboid movement on the RhoA-dependent kinase ROCK. Cancer cells can switch from one mec...

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Bibliografiska uppgifter
Huvudupphovsmän: Belgiovine, Cristina, Frapolli, Roberta, Bonezzi, Katiuscia, Chiodi, Ilaria, Favero, Francesco, Mello-Grand, Maurizia, Dei Tos, Angelo P., Giulotto, Elena, Taraboletti, Giulia, D'Incalci, Maurizio, Mondello, Chiara
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2010
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014295/
https://ncbi.nlm.nih.gov/pubmed/21209796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014154
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