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Insulin metabolism and the risk of Alzheimer disease: The Rotterdam Study

OBJECTIVE: Diabetes mellitus has been associated with an increased risk of Alzheimer disease (AD), but how it exerts its effect remains controversial. Possible pathophysiologic mechanisms are glucose toxicity and a direct effect of insulin on amyloid metabolism. Most studies had short follow-up, and...

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Detalhes bibliográficos
Main Authors: Schrijvers, E.M.C., Witteman, J.C.M., Sijbrands, E.J.G., Hofman, A., Koudstaal, P.J., Breteler, M.M.B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Academy of Neurology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014236/
https://ncbi.nlm.nih.gov/pubmed/21115952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3181ffe4f6
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