Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome

Adenovirus type 5 (Ad5) infection of macrophages results in rapid secretion of interleukin-1β (IL-1β) and is dependent on the inflammasome components NLRP3 and ASC and the catalytic activity of caspase-1. Using lentivirus-expressed short hairpin RNA (shRNA) and competitive inhibitors, we show that A...

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Bibliographic Details
Main Authors: Barlan, A. U., Griffin, T. M., Mcguire, K. A., Wiethoff, C. M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2011
Subjects:
Cellular Response to Infection
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014182/
https://ncbi.nlm.nih.gov/pubmed/20980503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01265-10
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