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Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome
Adenovirus type 5 (Ad5) infection of macrophages results in rapid secretion of interleukin-1β (IL-1β) and is dependent on the inflammasome components NLRP3 and ASC and the catalytic activity of caspase-1. Using lentivirus-expressed short hairpin RNA (shRNA) and competitive inhibitors, we show that A...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology (ASM)
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3014182/ https://ncbi.nlm.nih.gov/pubmed/20980503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01265-10 |
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