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Cathepsin B contributes to TNF-α–mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

TNF-α–induced apoptosis is thought to involve mediators from acidic vesicles. Cathepsin B (cat B), a lysosomal cysteine protease, has recently been implicated in apoptosis. To determine whether cat B contributes to TNF-α–induced apoptosis, we exposed mouse hepatocytes to the cytokine in vitro and in...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Guicciardi, M. Eugenia, Deussing, Jan, Miyoshi, Hideyuki, Bronk, Steven F., Svingen, Phyllis A., Peters, Christoph, Kaufmann, Scott H., Gores, Gregory J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2000
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Article
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC301415/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11067865/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9914
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