Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells

In collecting duct principal cells, aquaporin 2 (AQP2) is shuttled from intracellular vesicles to the plasma membrane upon vasopressin (VP) stimulation. VP activates adenylyl cyclase, increases intracellular cAMP, activating protein kinase A (PKA) to phosphorylate AQP2 on the COOH-terminal residue,...

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Pubblicato in:	J Clin Invest
Autori principali:	Bouley, Richard, Breton, Sylvie, Sun, Tian-xiao, McLaughlin, Margaret, Nsumu, Ndona N., Lin, Herbert Y., Ausiello, Dennis A., Brown, Dennis
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2000
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC301414/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11067864/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9594
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