Phenotypic characterization of epiphycan-deficient and epiphycan/biglycan double-deficient mice

OBJECTIVE: To characterize the in vivo role epiphycan (Epn) has in cartilage development and/or maintenance. METHODS: Epn-deficient mice were generated by disrupting the Epn gene in mouse embryonic stem cells. Epn/biglycan (Bgn) double-deficient mice were produced by crossing Epn-deficient mice with...

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Detalhes bibliográficos
Main Authors: Nuka, Satoshi, Zhou, Wei, Henry, Stephen P., Gendron, Christi M., Schultz, Jason B., Shinomura, Tamayuki, Johnson, Jan, Wang, Ying, Keene, Douglas R., Ramírez-Solis, Ramiro, Behringer, Richard R., Young, Marian F., Höök, Magnus
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013283/
https://ncbi.nlm.nih.gov/pubmed/19932218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2009.11.006
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