Nonsense Mediated Decay Resistant Mutations Are a Source of Expressed Mutant Proteins in Colon Cancer Cell Lines with Microsatellite Instability

BACKGROUND: Frameshift mutations in microsatellite instability high (MSI-High) colorectal cancers are a potential source of targetable neo-antigens. Many nonsense transcripts are subject to rapid degradation due to nonsense-mediated decay (NMD), but nonsense transcripts with a cMS in the last exon o...

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Detalhes bibliográficos
Main Authors: Williams, David S., Bird, Matthew J., Jorissen, Robert N., Yu, Yen Lin, Walker, Franscesa, Zhang, Hui Hua, Nice, Edouard C., Burgess, Antony W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013145/
https://ncbi.nlm.nih.gov/pubmed/21209843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016012
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