Elevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: implications for prostate cancer progressioan

BACKGROUND: Aldo-keto reductase (AKR) 1C family member 3 (AKR1C3), one of four identified human AKR1C enzymes, catalyzes steroid, prostaglandin, and xenobiotic metabolism. In the prostate, AKR1C3 is up-regulated in localized and advanced prostate adenocarcinoma, and is associated with prostate cance...

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Main Authors: Dozmorov, Mikhail G, Azzarello, Joseph T, Wren, Jonathan D, Fung, Kar-Ming, Yang, Qing, Davis, Jeffrey S, Hurst, Robert E, Culkin, Daniel J, Penning, Trevor M, Lin, Hsueh-Kung
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013086/
https://ncbi.nlm.nih.gov/pubmed/21134280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-672
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