Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase

The c-KIT receptor tyrosine kinase mediates the cellular response to stem cell factor (SCF). Whereas c-KIT activity is important for the proliferation of hematopoietic cells, melanocytes and germ cells, uncontrolled c-KIT activity contributes to the growth of diverse human tumors. Suppressor of cyto...

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Bibliographic Details
Main Authors: Zadjali, Fahad, Pike, Ashley C. W., Vesterlund, Mattias, Sun, Jianmin, Wu, Chenggang, Li, Shawn S. C., Rönnstrand, Lars, Knapp, Stefan, Bullock, Alex N., Flores-Morales, Amilcar
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013007/
https://ncbi.nlm.nih.gov/pubmed/21030588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.173526
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