SLUG-induced Elevation of D1 Cyclin in Breast Cancer Cells through the Inhibition of Its Ubiquitination

UbcH5c, a member of the UbcH5 family of protein ubiquitin conjugase E2 enzymes, is a critical component of biological processes in human cells, being the initial ubiquitinating enzyme of substrates like IκB, TP53, and cyclin D1. We report here that the metastasis regulator protein SLUG inhibits the...

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Bibliographic Details
Main Authors: Mittal, Mukul K., Singh, Kshipra, Misra, Smita, Chaudhuri, Gautam
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013006/
https://ncbi.nlm.nih.gov/pubmed/21044962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.164384
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