Bryostatin-1, a Naturally Occurring Antineoplastic Agent, Acts as a Toll-like Receptor 4 (TLR-4) Ligand and Induces Unique Cytokines and Chemokines in Dendritic Cells

Bryostatin-1 (Bryo-1), a natural macrocyclic lactone, is clinically used as an anti-cancer agent. In this study, we demonstrate for the first time that Bryo-1 acts as a Toll-like receptor 4 (TLR4) ligand. Interestingly, activation of bone marrow-derived dendritic cells (in vitro with Bryo-1) led to...

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Bibliographic Details
Main Authors: Ariza, Maria Eugenia, Ramakrishnan, Rupal, Singh, Narendra P., Chauhan, Ashok, Nagarkatti, Prakash S., Nagarkatti, Mitzi
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012980/
https://ncbi.nlm.nih.gov/pubmed/21036898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.135921
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