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Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein
The Yes-associated protein (YAP) is a transcription coactivator that plays a crucial role in organ size control by promoting cell proliferation and inhibiting apoptosis. The Hippo tumor suppressor pathway inhibits YAP through phosphorylation-induced cytoplasmic retention and degradation. Here we rep...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Cold Spring Harbor Laboratory Press
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3012936/ https://ncbi.nlm.nih.gov/pubmed/21205866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2000111 |
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