Viral capsid mobility: A dynamic conduit for inactivation

Mass spectrometry and fluorescent probes have provided direct evidence that alkylating agents permeate the protein capsid of naked viruses and chemically inactivate the nucleic acid. N-acetyl-aziridine and a fluorescent alkylating agent, dansyl sulfonate aziridine, inactivated three different viruse...

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Main Authors: Broo, Klas, Wei, Jing, Marshall, Dawn, Brown, Fred, Smith, Thomas J., Johnson, John E., Schneemann, Anette, Siuzdak, Gary
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2001
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC30128/
https://ncbi.nlm.nih.gov/pubmed/11226229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051598298
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