Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity.

Vero cell heparin-binding epidermal growth factor-like growth factor (HB-EGF) is synthesized as a 20- to 30-kDa membrane-anchored HB-EGF precursor (proHB-EGF). Localization and processing of proHB-EGF, both constitutive and 12-O-tetradecanoylphorbol 13-acetate (TPA)-inducible, was examined in Vero c...

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Detalhes bibliográficos
Main Authors: Goishi, K, Higashiyama, S, Klagsbrun, M, Nakano, N, Umata, T, Ishikawa, M, Mekada, E, Taniguchi, N
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC301256/
https://ncbi.nlm.nih.gov/pubmed/7579712
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