KMUP-3 attenuates ventricular remodelling after myocardial infarction through eNOS enhancement and restoration of MMP-9/TIMP-1 balance

BACKGROUND AND PURPOSE: Previously, 7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) has been shown to induce aortic smooth muscle relaxation through K(ATP) channel opening and endothelial nitric oxide synthase (eNOS) enhancement. We further investigated whether KMUP-3 prote...

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Hlavní autoři: Liu, Chung-Pin, Yeh, Jwu-Lai, Wu, Bin-Nan, Chai, Chee-Yin, Chen, Ing-Jun, Lai, Wen-Ter
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2011
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012411/
https://ncbi.nlm.nih.gov/pubmed/20840538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01024.x
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