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Molecular Determinants for PP2A Substrate Specificity: Charged Residues Mediate Dephosphorylation of Tyrosine Hydroxylase by the PP2A/B′ Regulatory Subunit

Together with protein phosphatase 1, protein phosphatase 2A (PP2A) contributes the bulk of Ser/Thr phosphatase activity in most cell types. The predominant form of PP2A is a heterotrimer of catalytic (C), scaffolding (A), and diverse regulatory subunits (B, B′, and B″). We have previously shown that...

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Autors principals: Saraf, Amit, Oberg, Elizabeth A., Strack, Stefan
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012350/
https://ncbi.nlm.nih.gov/pubmed/20017541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902160t
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