Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis

Squalene epoxidase, a membrane-associated enzyme that converts squalene to squalene 2,3-oxide, plays an important role in the maintenance of cholesterol homeostasis. In 1957, Bloch and colleagues identified a factor from rat liver cytosol termed “supernatant protein factor (SPF),” which promotes the...

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Detalhes bibliográficos
Main Authors: Shibata, Norihito, Arita, Makoto, Misaki, Yuko, Dohmae, Naoshi, Takio, Koji, Ono, Teruo, Inoue, Keizo, Arai, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC30123/
https://ncbi.nlm.nih.gov/pubmed/11226224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.041620398
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