Synthetic UDP-furanoses as potent inhibitors of mycobacterial galactan biogenesis

UDP-galactofuranose (UDP-Galf) is a substrate for two types of enzymes, UDP-galactopyranose mutase and galactofuranosyltransferases, which are present in many pathogenic organisms but absent from mammals. In particular, these enzymes are involved in the biosynthesis of cell wall galactan, a polymer...

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Autores principales: Peltier, Pauline, Beláňová, Martina, Dianišková, Petronela, Zhou, Ruokun, Zheng, Ruixiang Blake, Pearcey, Jean A., Joe, Maju, Brennan, Patrick J., Nugier-Chauvin, Caroline, Ferrières, Vincent, Lowary, Todd L., Daniellou, Richard, Mikušová, Katarína
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012269/
https://ncbi.nlm.nih.gov/pubmed/21168771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.10.014
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