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Design and assembly of new non-viral RNAi delivery agents by microwave-assisted quaternization (MAQ) of tertiary amines

RNA interference (RNAi), a gene-silencing phenomenon whereby double-stranded RNA (dsRNA) triggers the sequence-specific degradation of homologous mRNA. RNAi has been quickly and widely applied to discover gene functions and holds great potential to provide a new class of therapeutic agents. However,...

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Hlavní autoři: Ghosh, Animesh, Mukherjee, Koushik, Jiang, Xinpeng, Zhou, Ying, McCarroll, Joshua, Qu, James, Swain, Pamela M., Baigude, Huricha, Rana, Tariq M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012264/
https://ncbi.nlm.nih.gov/pubmed/20722369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc900482r
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