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The Aspartate-Semialdehyde Dehydrogenase of Edwardsiella ictaluri and Its Use as Balanced-Lethal System in Fish Vaccinology

asdA mutants of Gram-negative bacteria have an obligate requirement for diaminopimelic acid (DAP), which is an essential constituent of the peptidoglycan layer of the cell wall of these organisms. In environments deprived of DAP, i.e., animal tissues, they will undergo lysis. Deletion of the asdA ge...

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Main Authors: Santander, Javier, Xin, Wei, Yang, Zhao, Curtiss, Roy
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012122/
https://ncbi.nlm.nih.gov/pubmed/21209920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015944
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