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pRB induces Sp1 activity by relieving inhibition mediated by MDM2

pRB activates transcription by a poorly understood mechanism that involves relieving negative regulation of the promoter specificity factor Sp1. We show here that MDM2 inhibits Sp1-mediated transcription, that MDM2 binds directly to Sp1 in vitro as well as in vivo, and that MDM2 inhibits the DNA-bin...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Johnson-Pais, Teresa, Degnin, Catherine, Thayer, Mathew J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30117/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11226218/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051415898
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