Effect of disruption of actin filaments by Clostridium botulinum C2 toxin on insulin secretion in HIT-T15 cells and pancreatic islets.

To examine their role in insulin secretion, actin filaments (AFs) were disrupted by Clostridium botulinum C2 toxin that ADP-ribosylates G-actin. Ribosylation also prevents polymerization of G-actin to F-actin and inhibits AF assembly by capping the fast-growing end of F-actin. Pretreatment of HIT-T1...

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Veröffentlicht in:	Mol Biol Cell
Hauptverfasser:	Li, G, Rungger-Brändle, E, Just, I, Jonas, J C, Aktories, K, Wollheim, C B
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Cell Biology 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC301146/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7865885/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.5.11.1199
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