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An Intron 7 Polymorphism in APP Affects the Age of Onset of Dementia in Down Syndrome
People with Down syndrome (DS) develop Alzheimer's disease (AD) with an early age of onset. A tetranucleotide repeat, attt(5−8), in intron 7 of the amyloid precursor protein has been associated with the age of onset of AD in DS in a preliminary study. The authors examine the impact of this poly...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
SAGE-Hindawi Access to Research
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3010675/ https://ncbi.nlm.nih.gov/pubmed/21197396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/929102 |
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