Utility of organotypic raphe slice cultures to investigate the effects of sustained exposure to selective 5-HT reuptake inhibitors on 5-HT release

BACKGROUND AND PURPOSE: Selective 5-hydroxytryptamine (5-HT, serotonin) reuptake inhibitors (SSRIs) are widely used antidepressants and their therapeutic effect requires several weeks of drug administration. The delayed onset of SSRI efficacy is due to the slow neuroadaptive changes of the 5-hydroxy...

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Detalhes bibliográficos
Main Authors: Nagayasu, Kazuki, Yatani, Yumi, Kitaichi, Maiko, Kitagawa, Yutaka, Shirakawa, Hisashi, Nakagawa, Takayuki, Kaneko, Shuji
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010565/
https://ncbi.nlm.nih.gov/pubmed/20698856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00978.x
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