Phosphatidylinositol 3-kinase-δ up-regulates L-type Ca(2+) currents and increases vascular contractility in a mouse model of type 1 diabetes

BACKGROUND AND PURPOSE: Vasculopathies represent the main cause of morbidity and mortality in diabetes. Vascular malfunctioning in diabetes is associated with abnormal vasoconstriction and Ca(2+) handling by smooth muscle cells (SMC). Phosphatidylinositol 3-kinases (PI3K) are key mediators of insuli...

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Detalhes bibliográficos
Main Authors: Pinho, JF, Medeiros, MAA, Capettini, LSA, Rezende, BA, Campos, PP, Andrade, SP, Cortes, SF, Cruz, JS, Lemos, VS
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Research Papers with Commentaries
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010560/
https://ncbi.nlm.nih.gov/pubmed/20942845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00955.x
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