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The C-terminal domain of βIV-spectrin is crucial for KCNQ2 aggregation and excitability at nodes of Ranvier
The spectrin cytoskeleton has an important function in the targeting of proteins to excitable membrane domains. In axons, βIV-spectrin stabilizes voltage-gated sodium (Nav) channel clusters at nodes of Ranvier and axon initial segments, two regions crucial for the generation and conduction of action...
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| Formato: | Artigo |
| Idioma: | Inglês |
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Blackwell Science Inc
2010
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3010141/ https://ncbi.nlm.nih.gov/pubmed/20962009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.196022 |
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