Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response

Understanding how the immune system decides between tolerance and activation by antigens requires addressing cytokine regulation as a highly dynamic process. We quantified the dynamics of interleukin-2 (IL-2) signaling in a population of T cells during an immune response by combining in silico model...

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Hauptverfasser: Feinerman, Ofer, Jentsch, Garrit, Tkach, Karen E, Coward, Jesse W, Hathorn, Matthew M, Sneddon, Michael W, Emonet, Thierry, Smith, Kendall A, Altan-Bonnet, Grégoire
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010113/
https://ncbi.nlm.nih.gov/pubmed/21119631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2010.90
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